The odontode explosion: the origin of tooth-like structures in vertebrates.

Publication Type:Journal Article
Year of Publication:2010
Authors:Fraser, GJ, Cerny, R, Soukup, V, Bronner-Fraser, M, J Streelman, T
Journal:Bioessays
Volume:32
Issue:9
Pagination:808-17
Date Published:2010 Sep
ISSN:1521-1878
Keywords:Animals, Biological Evolution, Ectoderm, Endoderm, Epithelium, Odontogenesis, Tooth, Vertebrates
Abstract:

Essentially we show recent data to shed new light on the thorny controversy of how teeth arose in evolution. Essentially we show (a) how teeth can form equally from any epithelium, be it endoderm, ectoderm or a combination of the two and (b) that the gene expression programs of oral versus pharyngeal teeth are remarkably similar. Classic theories suggest that (i) skin denticles evolved first and odontode-inductive surface ectoderm merged inside the oral cavity to form teeth (the 'outside-in' hypothesis) or that (ii) patterned odontodes evolved first from endoderm deep inside the pharyngeal cavity (the 'inside-out' hypothesis). We propose a new perspective that views odontodes as structures sharing a deep molecular homology, united by sets of co-expressed genes defining a competent thickened epithelium and a collaborative neural crest-derived ectomesenchyme. Simply put, odontodes develop 'inside and out', wherever and whenever these co-expressed gene sets signal to one another. Our perspective complements the classic theories and highlights an agenda for specific experimental manipulations in model and non-model organisms.

DOI:10.1002/bies.200900151
Alternate Journal:Bioessays
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith